[Administration of procyanidolic oligomers in rats. Observed effects on changes in the cerebral biochemistry,...

Sodium arachidonate injection into the carotid artery of rats produces multiple cerebral infarction, evidenced clinically by behavioral disorders (that can be qualified using standard tests) and biochemically by various disturbances including increased cerebral contents of water, sodium and calcium. This study was carried out in several groups of 20 rats each. Two groups were treated preventively with 100 and 200 mg/kg respectively, Procyanidolic Oligomers (PCO) daily, given by gastric route for ten days. Observed disorders were significantly less severe and biochemistry changes were partly corrected in treated groups compared with the untreated group. This preventive effect was more significant in the group given 200 mg/kg/day.