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[Veralipride and menopause].

F Laffargue, J L Viala, G Durand

    La Semaine Des Hopitaux : Organe Fonde Par L'Association D'Enseignement Medical Des Hopitaux De Paris
    |September 1, 1983
    PubMed
    Summary
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    Veralipride offers a satisfactory non-hormonal therapy for menopausal hot flushes, particularly effective in natural menopause. This treatment demonstrated good clinical tolerance and no adverse effects on blood counts or hormonal levels.

    Area of Science:

    • Gynecology
    • Pharmacology
    • Menopause Research

    Background:

    • Menopause is characterized by climacteric manifestations, primarily hot flushes.
    • Hormonal therapy is a common treatment but carries potential risks.
    • There is a need for effective non-hormonal alternatives for managing menopausal symptoms.

    Purpose of the Study:

    • To evaluate the efficacy and safety of veralipride as a non-hormonal treatment for hot flushes in post-menopausal women.
    • To assess the impact of veralipride on climacteric manifestations and hormonal profiles.

    Main Methods:

    • A study involving twenty post-menopausal women (10 natural, 10 surgical menopause) experiencing hot flushes.
    • Administration of veralipride for three twenty-day courses.
    • Monitoring of clinical symptoms, tolerance, and biological parameters (blood counts, metabolism, BUN, transaminases).

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  • Hormonal assays (FSH, LH) were conducted in a subset of patients.

    • Main Results:

    • Satisfactory results were observed in two-thirds of the participants.
    • Natural menopause cases showed consistent positive responses to veralipride.
    • Veralipride demonstrated good clinical tolerance.
    • No significant modifications were noted in blood cell counts, glucid and lipid metabolism, BUN, or transaminases.
    • Hormonal assays indicated no impact of veralipride on Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH).

    Conclusions:

    • Veralipride is an effective non-hormonal therapy for menopausal hot flushes.
    • The treatment is well-tolerated and safe, with no observed adverse effects on biological or hormonal parameters.
    • Veralipride presents a valuable therapeutic option, especially for women with natural menopause seeking alternatives to hormone replacement therapy.