Diethyldithiocarbamic acid-methyl ester distribution, elimination, and LD50 in the rat after intraperitoneal...

Following the intraperitoneal administration of S35 diethyldithiocarbamic acid-methyl ester (S35 DDTC-Me) to male rats, maximal total radioactivity (S35) in most tissues was found 1 hr after dosing. Twelve hr after intraperitoneal S35 DDTC-Me, most of the total radioactivity was found in urine. The feces accounted for approximately 15% of the total radioactivity. No radioactivity was detected in the breath. The kidney exhibited the greatest uptake of radioactivity, while the least uptake was found in the brain and heart. Most of the radioactivity in the tissues was due to the inorganic sulfate. S35 DDTC-glucuronide was found in the gastrointestinal tract and feces. The LD50 for DDTC-Me given intraperitoneally to male rats and mice was 167 and 263 mg/kg, respectively. Symptoms of toxicity preceding death of the animals resembled those symptoms observed with disulfiram toxicity.