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Ranitidine does not affect gonadal function in man.

C Wang, K L Wong, K C Lam

    British Journal of Clinical Pharmacology
    |October 1, 1983
    PubMed
    Summary
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    Ranitidine treatment did not affect male reproductive hormones or sperm parameters in men with duodenal ulcers. This study indicates ranitidine is safe for gonadal function.

    Area of Science:

    • Pharmacology
    • Endocrinology
    • Gastroenterology

    Background:

    • Chronic duodenal ulcers are common gastrointestinal conditions.
    • Assessing the safety of commonly prescribed medications on reproductive health is crucial.

    Purpose of the Study:

    • To evaluate the impact of ranitidine on male gonadal function.
    • To determine if ranitidine affects reproductive hormone levels and sperm quality.

    Main Methods:

    • A randomized controlled trial involving 20 male subjects with chronic duodenal ulcers.
    • Subjects received either ranitidine (150 mg twice daily for 3 months, then 150 mg at night for 9 months) or a placebo for 3 months.
    • Measurements included serum testosterone, LH, FSH, prolactin, and sperm analysis (concentration, motility, morphology).

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    Main Results:

    • Ranitidine treatment did not significantly alter basal serum concentrations of testosterone, LH, FSH, or prolactin compared to placebo.
    • No significant changes were observed in sperm concentration, motility, or morphology in the ranitidine group.

    Conclusions:

    • Ranitidine does not appear to negatively affect male gonadal function.
    • The findings suggest ranitidine is safe concerning reproductive health in men with duodenal ulcers.