Androgen regulation of nuclear poly(A) polymerase activities in rat ventral prostate

The existence of nucleoplasmic and chromatin bound forms of poly(A) polymerase in the rat ventral prostate has been demonstrated. The levels of the prostate chromatin and nucleoplasmic poly(A) polymerase activities appeared to be under the influence of testosterone. Castration reduced both free and bound prostatic poly(A) polymerase activities to 30% of the normal values. Administration of testosterone to castrated rat resulted in increases in both nuclear poly(A) polymerase activities at 2-4 h after androgen replacement. The results suggest that post-transcriptional processing is under androgenic control.