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Behavior and binding: desensitization to alpha 1-adrenergic stimulation of acoustic startle is associated with a

D I Astrachan, D W Gallager, M Davis

    Brain Research
    |October 3, 1983
    PubMed
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    Desensitization to alpha 1-adrenergic agonists

    Area of Science:

    • Neuroscience
    • Pharmacology

    Background:

    • Alpha 1-adrenergic agonists can excite neural pathways.
    • The acoustic startle reflex is a model for studying excitatory effects.

    Purpose of the Study:

    • To investigate the time course and mechanism of desensitization to alpha 1-adrenergic agonists.
    • To examine the role of spinal alpha 1-adrenoceptor density in this process.

    Main Methods:

    • Intrathecal administration of phenylephrine, an alpha 1-adrenergic agonist.
    • Assessment of acoustic startle reflex.
    • Measurement of alpha 1-adrenoceptor binding in the lumbar spinal cord.

    Main Results:

    • Excitatory effects of alpha 1-adrenergic agonists on acoustic startle desensitized 6 hours post-administration.

    Related Experiment Videos

  • This desensitization correlated with a reduction in alpha 1-adrenoceptor sites in the lumbar spinal cord.

    • Conclusions:

    • Repeated or prolonged exposure to alpha 1-adrenergic agonists can lead to desensitization.
    • Downregulation of spinal alpha 1-adrenoceptors is a key mechanism underlying this desensitization.
    • Findings suggest a potential mechanism for modulating spinal excitability.