[1H-pyrazolo/1,2-b/phthalazines with anti-inflammatory activity]

The synthesis of forty-one 2,2,6,7-substituted 2,3,5,10-tetrahydro-1H-pyrazolo[1,2-b]phthalazine-1,3-diones A) by reaction of 4,4-di-substituted pyrazolidine-3,5-diones with substituted or unsubstituted alpha,alpha'-dibromoxylene and B) by tetrahydrophthalazine and 2-substituted malonic acid chlorides is described. The antinflammatory activity was tested on carrageenan oedema in comparison with phenylbutazone.