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Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

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Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
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Updated: Apr 29, 2026

An Allelotyping PCR for Identifying Salmonella enterica serovars Enteritidis, Hadar, Heidelberg, and Typhimurium
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IS200: a Salmonella-specific insertion sequence.

S Lam, J R Roth

    Cell
    |October 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Researchers discovered a new insertion sequence (IS) element, IS200, in Salmonella bacteria. This element

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    Area of Science:

    • Microbiology
    • Genetics
    • Bacterial Evolution

    Background:

    • Insertion sequence (IS) elements are mobile genetic components found in bacterial genomes.
    • Understanding the distribution and behavior of IS elements is crucial for comprehending bacterial genome dynamics and evolution.
    • Previous studies have characterized various IS elements, but their specific prevalence within certain bacterial groups remains an area of investigation.

    Purpose of the Study:

    • To identify and characterize a novel insertion sequence (IS) element in Salmonella.
    • To investigate the distribution and potential role of this new IS element across different bacterial species.
    • To assess the implications of IS element specificity for inter-bacterial transfer and evolutionary dynamics.

    Main Methods:

    • Genetic analysis to identify a novel IS element (IS200) based on its mutagenic properties (hisD984 mutation).
    • Genomic analysis to determine the copy number and presence of IS200 in Salmonella typhimurium strain LT2.
    • Comparative analysis of IS200 distribution across various Salmonella species and other enteric bacteria.

    Main Results:

    • A new IS element, designated IS200, was identified in Salmonella.
    • IS200 insertion was shown to cause the hisD984 mutation, and six copies were found in S. typhimurium LT2.
    • IS200 is prevalent in most examined Salmonella species but largely absent from other enteric bacteria, with observed transposition events.

    Conclusions:

    • The IS200 element exhibits high specificity for the Salmonella genus.
    • The restricted distribution of IS200 suggests that horizontal transfer of IS elements between bacterial groups might be less common than previously thought.
    • The specific prevalence of IS200 in Salmonella may indicate a selectively important role for this element within the genus.