Elevated benzodiazepine receptor density in forebrain of the mutant mouse "trembler" (TrJ)

The "Trembler" mouse, a neurologic mutant arising from a single dominant gene, is characterized by an action tremor thought to be caused by deficits in peripheral myelination. We found a significant elevation (twofold) over littermate control animals in the density of forebrain benzodiazepine receptors. This suggests that the deficit in peripheral myelination may not be the sole cause of the neurologic disorder.