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Related Experiment Videos

Posttransfusion hepatitis type A.

F B Hollinger, N C Khan, P E Oefinger

    JAMA
    |November 4, 1983
    PubMed
    Summary
    This summary is machine-generated.

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    Hepatology (Baltimore, Md.)·2001

    Hepatitis A virus (HAV) can spread through blood transfusions, causing posttransfusion hepatitis. This case confirms HAV transmission via donor blood, supported by laboratory evidence in both the recipient and the deceased donor.

    Area of Science:

    • Hepatology
    • Virology
    • Transfusion Medicine

    Background:

    • Hepatitis A virus (HAV) is a rare cause of posttransfusion hepatitis.
    • Documenting HAV transmission through blood transfusion requires robust laboratory evidence.

    Observation:

    • A 10-year-old girl developed hepatitis A 31 days after a packed red blood cell (RBC) transfusion.
    • The donor subsequently developed fatal hepatitis A.
    • HAV antigen was detected in the donor's liver and the transfused plasma.

    Findings:

    • HAV antigen density in donor liver and plasma matched infectious HAV particles.
    • Donor plasma was negative for anti-HAV antibodies but infectious when inoculated into a chimpanzee.
    • Chimpanzee inoculation resulted in laboratory-confirmed hepatitis A.

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    Implications:

    • This case provides definitive laboratory evidence of Hepatitis A virus transmission via blood transfusion.
    • Highlights the importance of screening for rare infectious agents in blood donations.
    • Underscores the potential for asymptomatic or pre-symptomatic blood donors to transmit HAV.