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A microcomputer based system for spike processing at low cost.

J Leendertz, D M Wright

    Journal of Neuroscience Methods
    |September 1, 1983
    PubMed
    Summary
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    This study presents a microcomputer-based system for quantifying neuronal activity by counting action potentials. It offers a flexible and cost-effective alternative to traditional ratemeters, with digital and analogue outputs.

    Area of Science:

    • Neuroscience
    • Biotechnology
    • Computer Engineering

    Background:

    • Conventional hard-wired ratemeters are often used for quantifying neuronal activity.
    • Existing systems may lack flexibility and incur high costs for data storage and modification.

    Purpose of the Study:

    • To introduce a novel microcomputer-based system for neuronal activity quantification.
    • To provide a cost-effective and adaptable alternative to conventional ratemeters.

    Main Methods:

    • The system utilizes a microcomputer with external electronic components (D/A converters, counters, latches) for action potential counting.
    • It processes neuronal signals in successive epochs, providing both digital (video monitor) and analogue (chart recorder) outputs.
    • System parameters like epoch time and analogue scaling are adjustable via switches without program interruption.

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    Main Results:

    • The microcomputer system successfully quantifies neuronal activity by counting action potentials.
    • Digital output displays counts and time; analogue output generates frequency/time histograms.
    • The system allows for real-time parameter adjustment and utilizes a C-MOS memory chip for program storage, offering immediate access and low cost.

    Conclusions:

    • The described microcomputer system provides a versatile and economical solution for neuronal activity quantification.
    • Its design facilitates easy modification and offers advantages over traditional storage methods.
    • This approach enhances flexibility in electrophysiological data acquisition and analysis.