Effects of base exchange reaction on the Na+, K+ ATPase in rat brain microsomes

Incorporation of ethanolamine and monomethylethanolamine into their corresponding phospholipid by the base exchange enzymes activated an Na+, K+-ATPase associated with a rat brain microsomes enriched preparation. The serine and dimethylethanolamine base exchange catalyzed incorporation reactions inhibited this particular Na+, K+-ATPase. These effects require Ca2+ and several other structural analogues which are not incorporated into phospholipid were without affect on this ATPase.