Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Target sequences for the C. elegans transposable element Tc1.

B Rosenzweig, L W Liao, D Hirsh

    Nucleic Acids Research
    |October 25, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Urological outcomes following pelvic exenteration for non-urological malignancies.

    Heliyon·2024
    Same author

    Ureteric stent versus percutaneous nephrostomy for acute ureteral obstruction - clinical outcome and quality of life: a bi-center prospective study.

    BMC urology·2019
    Same author

    Postoperative Urinary Leakage Following Partial Nephrectomy for Renal Mass: Risk Factors and a Proposed Algorithm for the Diagnosis and Management.

    Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society·2016
    Same author

    Attitudes and back belts in the workplace.

    Work (Reading, Mass.)·2014
    Same author

    Sperm isolation and biochemical analysis of the major sperm protein from Caenorhabditis elegans.

    Developmental biology·2010
    Same author

    Age-related differences in susceptibility to cisplatin-induced renal toxicity.

    Journal of applied toxicology : JAT·2009
    Same journal

    Neurochondrin promotes U5 snRNP maturation by regulating AAR2 release from PRPF8.

    Nucleic acids research·2026
    Same journal

    Elongationless start-stop elements are stress-resilient translation gates that are more repressive than uTranslons.

    Nucleic acids research·2026
    Same journal

    Evolution of the ribosomal exit tunnel through the eyes of the nascent chain.

    Nucleic acids research·2026
    Same journal

    Enhancing the performance and interpretability of epigenetic clocks.

    Nucleic acids research·2026
    Same journal

    FABIAN-variant 2026: improved prediction of the effects of DNA variants on transcription factor binding.

    Nucleic acids research·2026
    Same journal

    Structural and biochemical characterization of Grimontia hollisae thermostable direct hemolysin with DNA reveals first Vibrio hemolysin with nuclease activity.

    Nucleic acids research·2026
    See all related articles

    Two independent Tc1 transposable element insertions in Caenorhabditis elegans share target site homology. This suggests a novel insertion mechanism, potentially without target site duplication, challenging existing models of transposition.

    Area of Science:

    • Genetics
    • Molecular Biology
    • Developmental Biology

    Background:

    • Transposable elements (TEs) are mobile DNA sequences that play crucial roles in genome evolution.
    • The Tc1 element from Caenorhabditis elegans is a well-studied DNA transposon.
    • Understanding TE insertion mechanisms is fundamental to comprehending genome plasticity.

    Purpose of the Study:

    • To investigate the target site specificity and insertion characteristics of the Tc1 transposable element.
    • To elucidate the precise boundaries and potential duplication events associated with Tc1 insertions.
    • To explore novel mechanisms of transposable element insertion.

    Main Methods:

    • Comparative sequence analysis of independent Tc1 insertion sites.
    • Identification of target sequences and flanking regions.

    Related Experiment Videos

  • In silico analysis to determine element size and potential target site duplications.

    • Main Results:

    • Two independent Tc1 insertions in Caenorhabditis elegans exhibited homology at their target sites.
    • Both insertions occurred within palindromic TA/AT sequences.
    • The data suggest Tc1 may insert without target site duplication, implying a novel mechanism.

    Conclusions:

    • The homology and location of Tc1 insertions suggest a unique transposition process.
    • The possibility of Tc1 insertion without target site duplication warrants further investigation.
    • This finding could redefine our understanding of DNA transposon insertion mechanisms.