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[The Orf nodule].

P Dellamonica, E Bernard, J P Ortonne

    La Semaine Des Hopitaux : Organe Fonde Par L'Association D'Enseignement Medical Des Hopitaux De Paris
    |September 15, 1983
    PubMed
    Summary
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    Human Orf disease, a rare skin condition caused by a Parapox virus, can spread from infected animals like sheep and goats. This report details three family cases, highlighting the need for practitioner awareness of this zoonotic viral infection.

    Area of Science:

    • Dermatology
    • Virology
    • Zoonotic Diseases

    Background:

    • Orf disease is a benign, exceptional dermatologic condition caused by a Parapox virus.
    • In livestock such as sheep and goats, this infection is known as Ecthyma Contagiosum.
    • Human transmission occurs through contact with infected animals.

    Observation:

    • Three cases of Orf disease were documented within the same family.
    • Electron microscopy confirmed typical viral particles in the skin biopsy of one patient.
    • Despite microscopic evidence, viral cultures were unsuccessful in isolating the pathogen.

    Findings:

    • Orf disease presents as a rare zoonotic viral infection in humans.
    • Diagnosis can be challenging due to difficulties in pathogen recovery.

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  • Electron microscopy serves as a key diagnostic tool when cultures fail.

    • Implications:

    • Increased awareness among medical practitioners is crucial for timely diagnosis and management of Orf disease.
    • Understanding the transmission routes from animals to humans is vital for public health.
    • Further research into diagnostic methods for Parapox virus infections is warranted.