[Effect of sisomicin i on elements of the peripheral nervous system]

In long-term experiments with anesthetized cats and albino mice sisomicin and gentamicin were found to impair the impulse conduction in the skeletal muscle synapses and in the ganglia of the sympathetic and parasympathetic nervous systems. Comparison of the drug doses inducing the above effects in experimental animals showed that the neuroblocking activity of sisomicin was almost 3 times higher than that of gentamicin. Since the therapeutic doses of sisomicin used in the treatment of patients are 2.5-3 times lower than the respective doses of gentamicin, it must be considered that both the drugs had the same ranges of the therapeutic activity from the standpoint of their side effects.