Immunological aspects of hepatocellular carcinoma in the guinea-pig

Experimental observations were made on hepatic cancer induced with diethylnitrosamine (DEN) in guinea-pigs. Two cancer cell lines have been established in tissue culture and their antigenicity investigated. Tumour antignes were not found on normal liver cells, liver cells damaged wtih carbon tetrachloride and fetal liver cells obtained from fetuses more than 35 days old. The possibility of using immunological techniques to investigate the antigenicity of human cancer is discussed.