[Optimation of postoperative prophylaxis of thrombosis in gynaecology (author's transl)]

The prophylactic effect of heparin dihydroergotamine, the combination of these two (Heparin-Dihydergot) and acetylsalicylic-acid in the prevention of deep vein thrombosis was investigated in a prospective randomized clinical trial involving 454 patients. Evidence of thrombosis was detected by the 125I-fibrinogen-uptake-test in 22 out of 75 patients (29.3%) in the control group. The application of 2 x 0.5 mgDHE or 2 x 5000 IU of heparin reduced the incidence of deep vein thrombosis to 7%, which is statistically significant. After simultaneous prophylaxis with both drugs the incidence dropped to 2%. The combined use of DHE and heparin may be considered the best prophylactic regimen available for lowering postoperative DVT. After application of 3 x 0.5 g of ASS frequency of DVT decreased only to 15.3% and shows poor prophylactic efficacy.