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Right ventricular aneurysms complicating encephalomyocarditis virus myocarditis in mice
Abstract:
Inbred strains of BALB/c, C3H/He and DBA/2 mice were inoculated intraperitoneally with the M variant of encephalomyocarditis virus with a titer of 100 TCD50 per 0.1 ml and followed up to the 8th month. Right ventricular aneurysms were noticed in 7 hearts of these 647 mice (1.1%) sacrificed from 8 to 10 months after inoculation with the virus. Myocardial fibers of the right ventricle were destroyed transmurally and fibrosis was found in the chronic stage. This study demonstrated that viral myocarditis may cause right ventricular aneurysms, albeit infrequently, suggesting a pathogenetic role of viral infection in right ventricular dysplasia or Uhl's anomaly.
Insights
Viral myocarditis can infrequently cause right ventricular aneurysms in mice. This study suggests a potential link between viral infections and conditions like right ventricular dysplasia.
Area of Science:
- Virology
- Cardiology
- Pathology
Background:
- Encephalomyocarditis virus (EMCV) is a known cause of myocarditis.
- The long-term sequelae of viral myocarditis, particularly on right ventricular structure, are not fully understood.
Purpose of the Study:
- To investigate the potential for encephalomyocarditis virus infection to induce chronic cardiac abnormalities.
- To determine if viral myocarditis can lead to the development of right ventricular aneurysms.
Main Methods:
- BALB/c, C3H/He, and DBA/2 mice were inoculated with the M variant of EMCV.
- Mice were monitored for up to 8 months post-infection.
- Cardiac tissues were examined for pathological changes, focusing on the right ventricle.
Main Results:
- Right ventricular aneurysms were observed in 1.1% of infected mice (7 out of 647).
- These aneurysms developed between 8 and 10 months after viral inoculation.
- Histological analysis revealed transmural destruction of myocardial fibers and fibrosis in the chronic stage.
Conclusions:
- Viral myocarditis, induced by EMCV, can infrequently result in right ventricular aneurysms.
- These findings suggest a possible pathogenetic role for viral infections in conditions such as right ventricular dysplasia and Uhl's anomaly.