Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Left atrial myxoma. An ultrastructural study.

P Chopra, V K Sharma

    Japanese Heart Journal
    |July 1, 1983
    PubMed
    Summary

    Cardiac myxomas, often found in the left atrium, show diverse mesenchymal cell differentiation under electron microscopy. These tumors may arise from subendocardial multipotential cells.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Time-resolved relaxation and fragmentation of polycyclic aromatic hydrocarbons investigated in the ultrafast XUV-IR regime.

    Nature communications·2021
    Same author

    Aspergillus vertebral osteomyelitis in immunocompetent patients.

    Indian journal of orthopaedics·2012
    Same author

    Acute massive splenic infarction with complete liquefaction of the spleen in sickle cell disease.

    Hematology/oncology and stem cell therapy·2011
    Same author

    Mucin-producing signet ring cell adenoma of the thyroid.

    Indian journal of pathology & microbiology·2008
    Same author

    Single-pill amlodipine/atorvastatin helps patients of diverse ethnicity attain recommended goals for blood pressure and lipids (the Gemini-AALA study).

    Journal of human hypertension·2008
    Same author

    Inflammatory pseudotumor of lymph nodes presenting as pyrexia of unknown origin.

    Indian journal of pathology & microbiology·2008

    Area of Science:

    • Cardiovascular Pathology
    • Cell Biology
    • Electron Microscopy

    Background:

    • Cardiac myxomas are the most common primary heart tumors.
    • They typically occur in the left atrium and can be associated with systemic symptoms.
    • Ultrastructural analysis provides detailed insights into tumor composition.

    Purpose of the Study:

    • To characterize the ultrastructural features of cardiac myxomas.
    • To identify the cell types and differentiation states within cardiac myxomas.
    • To elucidate the potential cellular origin of cardiac myxomas.

    Main Methods:

    • Electron microscopy was performed on four surgically excised cardiac myxomas.
    • Detailed ultrastructural examination of cellular morphology and extracellular matrix was conducted.
    • Identification of various cell types, including myofibroblasts, macrophages, and lymphocytes.

    Main Results:

    • All myxomas were located in the left atrium, with most exhibiting a stalk.
    • Diverse mesenchymal cells were observed, including smooth muscle-like cells, fibroblasts, endothelium, and myofibroblasts.
    • Macrophages, lymphocytes, and plasma cells were present in small numbers; hematopoietic foci and calcification were absent.
    • The extracellular matrix contained fine electron-dense granules and sparse collagen fibers.

    Conclusions:

    • Cardiac myxomas exhibit significant cellular heterogeneity with evidence of mesenchymal differentiation.
    • The findings support the hypothesis that myxomas may represent either hyperplasia or a true neoplasm of subendocardial multipotential cells.
    • Ultrastructural analysis is crucial for understanding the complex cellular origins and composition of cardiac myxomas.

    Related Experiment Videos