Interaction of series and parallel dead space in the lung

The volume of ventilation delivered to unperfused zones of the respiratory system (respiratory dead space) can be divided into the volume occupied by the conducting airways (series dead space) and the volume of unperfused alveolar space (parallel dead space). The effect of the interaction between these two components of dead space on steady-state gas exchange was first evaluated with a mathematical model. The presence of both parallel and series dead space was predicted to underestimate the dead space measured by the inert gas elimination technique (VDIG). This error was largest when the volumes of parallel and series dead space were equal. The size of the parallel dead space in the model could be calculated from measurements of VDIG made before and after adding a series dead space of known volume. In 16 anesthetized dogs series and parallel dead space were quantitated using the multiple inert gas elimination technique with addition of known volumes of series dead space. In five normal dogs, the series and parallel dead space averaged 20% and 13% of the tidal volume, respectively. In eleven dogs with the left pulmonary artery occluded the parallel dead space averaged 26%. This method represents the first means of quantitating these two anatomically separate components of wasted ventilation.