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[Glomerulopathies in the aged (excluding diabetes)]
La Semaine Des Hopitaux : Organe Fonde Par L'Association D'Enseignement Medical Des Hopitaux De Paris
|November 10, 1983
Summary
Glomerular diseases in older adults present similar symptoms, necessitating histological examination for diagnosis. Early investigation and treatment, similar to younger patients, can yield significant positive outcomes with manageable risks.
Area of Science:
- Nephrology
- Geriatric Medicine
- Pathology
Context:
- Glomerular diseases affect non-diabetic patients over sixty.
- Retrospective study of 55 cases.
- Focus on primary and secondary glomerular pathologies.
Purpose:
- To analyze the characteristics and outcomes of glomerular diseases in elderly non-diabetic patients.
- To evaluate diagnostic challenges and treatment efficacy.
- To determine the risks associated with investigations in this demographic.
Summary:
- Minimal changes glomerulopathy (25.4%) and amyloidosis (21.8%) were common. Symptoms were often indistinguishable pre-histology.
- Corticosteroids showed significant efficacy in minimal changes and extracapillary proliferative glomerulopathies, with 9 of 14 patients improving.
- One patient experienced a fatal complication (sigmoid perforation) while on corticosteroids.
Impact:
- Histological examination is crucial for accurate diagnosis in elderly patients with glomerular disease.
- Diagnostic and treatment approaches used for younger patients appear applicable to older adults.
- Investigations in older patients do not carry a significantly higher risk, supporting comprehensive workup.