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Published on: April 22, 2010

Histopathologic changes in macaques with an acquired immunodeficiency syndrome (AIDS)

N W King, R D Hunt, N L Letvin

    The American Journal of Pathology
    |December 1, 1983
    PubMed

    Insights

    This study details the histopathology of Acquired Immunodeficiency Syndrome (AIDS) in macaque monkeys. Researchers identified opportunistic infections and unusual conditions like lymphoproliferative disorders and amyloidosis.

    Area of Science:

    • Veterinary Pathology
    • Primate Immunology
    • Infectious Diseases

    Background:

    • A previous study documented the clinical presentation of Acquired Immunodeficiency Syndrome (AIDS) in a macaque colony.
    • This research expands on that by examining the pathological findings in affected animals.

    Purpose of the Study:

    • To conduct a histopathological review of tissues from macaque monkeys exhibiting AIDS.
    • To identify opportunistic infections and other pathological conditions associated with the syndrome in this animal model.

    Main Methods:

    • Histopathological examination of tissues from 16 macaques with AIDS at necropsy.
    • Analysis of various organs for signs of infection and neoplastic or degenerative processes.

    Main Results:

    • Opportunistic infections including cytomegalovirus (CMV), simian virus 40 (SV-40), and noma were identified.
    • Unusual findings included lymphoproliferative disorders (ranging from nodules to lymphoma) in 4 animals.
    • Retroperitoneal fibrosis was noted in 3 animals, and amyloidosis was observed in several, including intestinal mucosal involvement.

    Conclusions:

    • Histopathology reveals a spectrum of opportunistic infections and novel pathological conditions in macaques with AIDS.
    • The findings highlight the utility of this macaque model for studying AIDS-related pathologies.
    • Further research into these specific conditions may offer insights into disease mechanisms and potential treatments.

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