Related Experiment Video

Updated: May 10, 2026

Quantitative Analysis of Cancer Metastasis using an Avian Embryo Model
08:40

Quantitative Analysis of Cancer Metastasis using an Avian Embryo Model

Published on: May 31, 2011

A recovered avian myelocytomatosis virus that induces lymphomas in chickens: pathogenic properties and their

P J Enrietto, L N Payne, M J Hayman

    Cell
    |December 1, 1983
    PubMed

    Insights

    Avian myelocytomatosis virus MC29, typically causing myeloid and other tumors, was found to induce lymphoid tumors in chickens. This novel finding is linked to a hybrid myc gene in the recovered HBI virus.

    Area of Science:

    • Oncology
    • Virology
    • Molecular Biology

    Background:

    • Avian myelocytomatosis virus MC29 (MC29) normally induces myelocytomas and kidney/liver tumors via its v-myc gene.
    • Lymphoid tumors in chickens are typically associated with c-myc gene activation by lymphoid leukosis virus integration.

    Purpose of the Study:

    • To investigate the oncogenic potential of a recovered MC29 virus (HBI) with a hybrid myc gene.
    • To determine if HBI can induce lymphoid tumors and elucidate the underlying molecular mechanisms.

    Main Methods:

    • Analysis of a recombinant MC29 virus (HBI) containing both c-myc and v-myc sequences.
    • Inoculation of HBI into chickens to observe tumor development.
    • Molecular analysis of tumors, including proviral DNA integration and protein expression.

    Main Results:

    • HBI inoculation induced lymphoid tumors in chickens, independent of the bursa.
    • Tumors comprised both T and B lymphocytes.
    • HBI proviral DNA was detected in most tumors, and the HBI gag-myc fusion protein (p108) was present in tumor cells.

    Conclusions:

    • The hybrid myc gene in HBI can induce lymphoid tumors, expanding the known disease spectrum of MC29.
    • These findings offer insights into the target-cell specificity of myc-driven oncogenesis.

    More Related Videos

    Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis10:04

    Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

    Published on: May 1, 2015

    An Ex Vivo Chicken Primary Bursal-cell Culture Model to Study Infectious Bursal Disease Virus Pathogenesis07:26

    An Ex Vivo Chicken Primary Bursal-cell Culture Model to Study Infectious Bursal Disease Virus Pathogenesis

    Published on: October 4, 2018

    Related Concept Videos

    Mechanisms of Retrovirus-induced Cancers01:51

    Mechanisms of Retrovirus-induced Cancers

    Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
    Rous Sarcoma Virus (RSV) and Cancer01:03

    Rous Sarcoma Virus (RSV) and Cancer

    Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
    RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
    Cytomegalovirus Disease01:27

    Cytomegalovirus Disease

    Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...