Collagenase activity in the granulocytes of patients with various liver diseases

Studies were conducted on collagenase activity on peripheral granulocytes of patients with various liver diseases. Total collagenase activity increased significantly in chronic active hepatitis (CAH) and in liver cirrhosis (LC), and, in these disorders, it correlated with the extent to which hepatic fibrosis has progressed. Active collagenase activity increased in CAH, but no differences from normal controls were found in other liver diseases. These results suggest that total collagenase may reflect the degree of hepatic fibrosis, and that active collagenase may be related to chronic active hepatitis lesions.