Autoradiographic localization of prazosin binding sites in rat kidney

[3H]Prazosin is a selective ligand for alpha 1-adrenoceptors. Using an in vitro autoradiographic technique specific binding of [3H]prazosin has been demonstrated, mainly to the renal cortex of the rat. These results provide further evidence that, in the rat, there is a high density of alpha 1-adrenoceptors within the renal cortex.