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Updated: Aug 9, 2026

Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions
Published on: September 17, 2014
[Pharmacokinetic profile of a slow-release ketoprofen preparation]
Abstract:
Kinetics of ketoprofen release in man from a sustained-release preparation (150 mg) and from capsules (3 X 50 mg) were studied comparatively in 10 healthy adults. Bioavailability of the slow-release preparation is similar to that of capsules : surfaces under the serum concentration curves and urinary elimination were found to be identical. In the sustained-release preparation the immediately available layer (75 mg) ensures achievement of maximal serum concentrations amounting to 59% of those obtained with capsules, after the same time interval. The slow-release layer (75 mg) produces higher serum concentrations from the third hour on, justifying administration of the formulation in two daily doses.
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