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[Ketoprofen-aspirin interaction].

Y Pawlotsky, J Y Louboutin, G Chales

    La Semaine Des Hopitaux : Organe Fonde Par L'Association D'Enseignement Medical Des Hopitaux De Paris
    |December 12, 1983
    PubMed
    Summary
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    Combining ketoprofen and aspirin for inflammatory joint disease offers no clinical benefit and may reduce ketoprofen's anti-inflammatory effects. This combination is not recommended for patients.

    Area of Science:

    • Pharmacology
    • Rheumatology
    • Clinical Trials

    Background:

    • Chronic inflammatory joint diseases require effective pain and inflammation management.
    • Non-steroidal anti-inflammatory drugs (NSAIDs) like ketoprofen and aspirin are commonly used.
    • Investigating drug interactions is crucial for optimizing therapeutic outcomes.

    Purpose of the Study:

    • To evaluate the clinical efficacy and pharmacokinetic interactions of ketoprofen when co-administered with aspirin.
    • To determine if combining ketoprofen and aspirin offers superior anti-inflammatory effects in patients with inflammatory joint disease.

    Main Methods:

    • A double-blind, crossover study involving 18 patients with chronic inflammatory joint disease.
    • Patients received ketoprofen (300 mg/day) alone or combined with aspirin (1,500 mg/day) in successive five-day sequences.

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  • Clinical efficacy assessed using Ritchie's articular index and Lee's functional index; pharmacokinetic analysis of serum ketoprofen; erythrocyte sedimentation rate (ESR) measured.

    • Main Results:

    • Ketoprofen's bioavailability and pharmacokinetics were not significantly altered by the addition of aspirin.
    • Clinical assessments showed ketoprofen was equally effective whether given alone or with aspirin.
    • Aspirin appeared to reduce ketoprofen's anti-inflammatory biological activity (ESR), though not reaching statistical significance.

    Conclusions:

    • Combining ketoprofen and aspirin is clinically unnecessary for treating inflammatory joint disease.
    • The co-administration of ketoprofen and aspirin may diminish the anti-inflammatory efficacy of ketoprofen.
    • Avoid combining ketoprofen and aspirin due to potential harm and lack of benefit.