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Updated: Aug 19, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
A fetus with recombinant of chromosome 8 inherited from her carrier father
Abstract:
A pericentric inversion of chromosome 8, inv(8)(p23q22), in a male carrier resulted in an unbalanced recombinant, rec(8)dup q, inv(8)(p23q22), which was diagnosed prenatally. The features seen in the aborted fetus resembled the features seen in a previously affected child who received the identical recombinant from her carrier mother. In this particular inversion involving chromosome 8, both male and female carriers risk producing an unbalanced progeny. Different familial pericentric inversions are reviewed for the presence or absence of unbalanced recombinants.
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