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Related Experiment Videos

[Side effects of ketoconazole].

E Haneke

    Zeitschrift Fur Hautkrankheiten
    |November 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Ketoconazole is an oral antifungal medication generally well-tolerated. High doses (400 mg daily) may impact testosterone production, and rare liver issues can occur.

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    Area of Science:

    • Pharmacology
    • Mycology
    • Endocrinology

    Context:

    • Ketoconazole is a broad-spectrum antifungal agent.
    • Oral administration is a common route for systemic antifungals.
    • Patient tolerance and potential side effects are critical considerations for drug safety.

    Purpose:

    • To evaluate the safety and tolerability of ketoconazole.
    • To identify potential adverse effects associated with ketoconazole treatment.
    • To investigate the impact of ketoconazole dosage on hormonal biosynthesis.

    Summary:

    • Ketoconazole is typically well-tolerated as an oral antifungal medication.
    • Idiosyncratic liver reactions, occurring below 1:10,000 incidence, are independent of dose or duration.
    • Dosages of 400 mg daily or higher may inhibit testosterone biosynthesis.

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    Impact:

    • Provides crucial safety information for clinicians prescribing ketoconazole.
    • Highlights the need for monitoring liver function in patients on ketoconazole.
    • Informs about potential endocrine side effects, particularly testosterone inhibition at higher doses.