Related Experiment Videos
[Wilms' tumor. Clinico-prognostic correlates]
Insights
This study reports on 42 pediatric Wilms' tumor cases, finding a 72% five-year survival rate. Survival is linked to tumor stage, patient age, and lymph node involvement in pediatric cancer patients.
Area of Science:
- Pediatric Oncology
- Nephrology
- Cancer Research
Context:
- Presents findings from a series of 42 pediatric patients diagnosed with Wilms' tumor over an 11-year period.
- Highlights demographic data: a female-to-male ratio of 1.5:1 and 85% of patients diagnosed under 5 years old.
Purpose:
- To report on the clinical characteristics, pathological findings, and survival outcomes of pediatric Wilms' tumor.
- To analyze the relationship between survival rates and prognostic factors such as tumor stage, patient age, and lymph node spread.
- To discuss the efficacy of preoperative chemotherapy in managing Wilms' tumor.
Summary:
- The majority of Wilms' tumors were Stage I (38%), with Stages III and IV also noted. Pathological findings were evaluated using Beckwith's criteria.
- Achieved a 5-year survival rate of 72% and a tumor-free survival rate of 62%.
- A significant correlation was observed between survival and tumor stage, patient age, and the presence of intra-abdominal lymph node metastasis.
Impact:
- Provides crucial data for understanding Wilms' tumor epidemiology and prognosis in children.
- Informs treatment strategies by highlighting the importance of staging, age, and lymph node status in pediatric kidney cancer.
- Contributes to the ongoing discussion on optimizing preoperative chemotherapy protocols for improved outcomes in pediatric Wilms' tumor patients.
Abstract:
A series of 42 children with Wilms' tumor collected in 11 years is reported. The female-to-male ratio was 1,5:1 and 85 per cent of the patients were under 5 years at diagnosis. The majority of the tumors were Stage I (38 per cent) followed by Stages III and IV. Pathological findings following Belkwith's criteria are commented upon. The 5 year survival was 72 per cent, and tumor-free survival was 62 per cent. There was a clear relationship between survival and Stage, age and the presence or absence of intra-abdominal lymph-node spread. Efficacity of preoperative chemotherapy and its' influence on the stage of tumor at operation is discussed.