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Papular acrodermatitis with cytomegalovirus hepatitis
Archives of Disease in Childhood
|December 1, 1983
Insights
Gianotti-Crosti syndrome, typically linked to Hepatitis B, can also be caused by cytomegalovirus infection. This case highlights a new association for this childhood rash and liver inflammation syndrome.
Area of Science:
- Pediatric Infectious Diseases
- Hepatology
- Dermatology
Background:
- Gianotti-Crosti syndrome (papular acrodermatitis of childhood) is a recognized dermatological condition.
- It is classically associated with Hepatitis B virus (HBV) infection, specifically Hepatitis B surface antigen (HBsAg).
Observation:
- A case report of an infant presenting with Gianotti-Crosti syndrome is detailed.
- The infant exhibited classic symptoms of the syndrome.
Findings:
- Serological testing revealed evidence of cytomegalovirus (CMV) infection in the affected infant.
- This finding challenges the classical association with HBsAg, suggesting CMV as a potential causative agent.
Implications:
- This case broadens the etiological understanding of Gianotti-Crosti syndrome.
- It suggests that cytomegalovirus should be considered in the differential diagnosis of Gianotti-Crosti syndrome, particularly in infants.
Abstract:
The syndrome of papular acrodermatitis of childhood with hepatitis (Gianotti-Crosti syndrome) is classically considered to be associated with hepatitis B surface antigen (HBsAg) infection. We report an infant with the syndrome, but with serological evidence of infection by cytomegalovirus.