Search research articles

Search research articles

Related Experiment Videos

[Effect of beta-endorphin on endocrine function].

V N Slavnov, G V Valueva, E V Luchitskiĭ

Biulleten' Eksperimental'Noi Biologii I Meditsiny

|December 1, 1983

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Russian Cross-disciplinary Consensus on the diagnosis and treatment of spondyloarthritis associated with inflammatory bowel diseases].

Terapevticheskii arkhiv·2025

Same author

[Sporadic and group imported cases of hepatitis E in St. Petersburg].

Zhurnal mikrobiologii, epidemiologii i immunobiologii·2013

Same author

[Chronic viral hepatitis in St.Petersburg].

Zhurnal mikrobiologii, epidemiologii i immunobiologii·2013

Same author

[Evaluation of antiepileptic effects of cortexin in a model of convulsions].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2012

Same author

[Clinical and economic expedience of ertapenem therapy of complicated urinary tract infection].

Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]·2011

Same author

[Akatinol memantine in patients with vascular cognitive disorders].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2011

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Beta-endorphin influences ACTH, prolactin, corticosterone, and aldosterone secretion, but not thyrotropin. Its effects on hormone levels peak at 20 minutes, with potential links to altered brain dopamine levels.

Area of Science:

Neuroendocrinology
Hormone Secretion Regulation

Background:

Beta-endorphin is an endogenous opioid peptide with known regulatory roles in the endocrine system.
Understanding beta-endorphin's specific effects on pituitary hormone release is crucial for neuroendocrine research.

Purpose of the Study:

To investigate the impact of beta-endorphin on the secretion of various pituitary hormones, including ACTH, prolactin, corticosterone, aldosterone, and somatotrophin.
To determine the temporal dynamics of these hormonal changes following beta-endorphin administration.
To explore potential underlying mechanisms, such as changes in brain monoamines.

Main Methods:

Intravenous injection of beta-endorphin in animal models.
Measurement of hormone concentrations (ACTH, prolactin, corticosterone, aldosterone, somatotrophin, thyrotropin) at specific time points (5, 20, and 60 minutes) post-injection.

Related Experiment Videos

Analysis of brain monoamine levels, particularly dopamine.

Main Results:

Beta-endorphin significantly affected ACTH, prolactin, corticosterone, aldosterone, and somatotrophin secretion, but not thyrotropin.
Hormonal level increases were observed as early as 5 minutes, with maximal concentrations at 20 minutes post-injection.
While prolactin, corticosterone, and aldosterone returned to baseline by 60 minutes, ACTH remained elevated compared to controls.
A decrease in brain dopamine levels was suggested as a potential mechanism.

Conclusions:

Beta-endorphin plays a significant role in modulating the secretion of several key pituitary hormones.
The observed hormonal responses exhibit a distinct time course, with a notable sustained elevation of ACTH.
Alterations in central dopaminergic pathways may mediate some of beta-endorphin's neuroendocrine effects.