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Ganglionic blockade by d-amphetamine.

D Christ

    European Journal of Pharmacology
    |December 9, 1983
    PubMed
    Summary

    d-amphetamine blocks ganglionic transmission through a muscarinic mechanism, distinct from catecholamines. This blockade is frequency-dependent and involves muscarinic receptors, differing from catecholamine actions.

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    Area of Science:

    • Neuroscience
    • Pharmacology

    Background:

    • Ganglionic transmission is crucial for autonomic nervous system function.
    • Understanding drug mechanisms at the ganglionic level is vital for therapeutic development.

    Purpose of the Study:

    • To investigate the mechanism of d-amphetamine's action on ganglionic transmission in the hamster stellate ganglion.
    • To differentiate the ganglionic blockade mechanism of d-amphetamine from that of catecholamines.

    Main Methods:

    • Electrophysiological recording of compound action potentials in isolated hamster stellate ganglia.
    • Dose-response and frequency-dependence studies of d-amphetamine.
    • Assessment of interactions with adrenergic (phentolamine, propranolol) and muscarinic (atropine) antagonists, and hexamethonium.

    Main Results:

    • d-amphetamine induced a slow-onset, frequency-dependent blockade of ganglionic transmission.
    • The frequency-dependence was attenuated by atropine, suggesting a muscarinic mechanism.
    • High d-amphetamine concentrations caused postganglionic discharges and potentiated cholinergic agonists, with rapid tolerance development.
    • The blockade mechanism differs from that of catecholamines.

    Conclusions:

    • d-amphetamine's ganglionic blockade involves a muscarinic mechanism, distinct from catecholamine-induced blockade.
    • Frequency-dependence and muscarinic receptor interaction are key features of d-amphetamine's ganglionic effects.

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