Levels of homocytotropic antibody in hereditarily asplenic, splenectomized and normal mice

No significant differences were detected in circulating levels of IgE or IgG1 in hereditarily asplenic (Dh/+) or splenectomized mice compared to normal controls (+/+). These findings suggest that the spleen plays a minor role in the regulation of IgG1 and IgE production in this mouse line.