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Primary structural sequence polymorphism in the human class II MHC antigen 33.1.

M C Kuo, X M Li, G E Marti

    Immunogenetics
    |January 1, 1984
    PubMed
    Summary
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    Monoclonal antibody 33.1 identifies a unique human major histocompatibility complex antigen. This study reveals two main variants of the 33.1 antigen, linked to MB specificities, with potential implications for B-cell activation.

    Area of Science:

    • Immunogenetics
    • Molecular immunology
    • Human Major Histocompatibility Complex (MHC) research

    Background:

    • Monoclonal antibody (mAb) 33.1 targets a novel non-DR, class II human MHC antigen, designated 33.1.
    • This antigen exhibits distinct cellular distribution and primary structure compared to other known class II antigens.
    • Understanding the polymorphism of MHC antigens is crucial for immune system research and transplantation.

    Purpose of the Study:

    • To conduct a comparative N-terminal sequence analysis of the 33.1 antigen.
    • To determine the extent of polymorphism within the 33.1 antigen.
    • To investigate the relationship between the 33.1 antigen and other human MHC class II antigens, specifically MB types.

    Main Methods:

    • N-terminal amino acid sequencing of the 33.1 antigen.

    Related Experiment Videos

  • Comparative analysis using ten B lymphoblastoid cell lines with diverse DR and MB types.
  • Utilized monoclonal antibody 33.1 for antigen identification and characterization.

    • Main Results:

    • Both alpha and beta chains of the 33.1 antigen are homologous to murine I-A antigen chains.
    • Sequence analysis identified two major variants of 33.1, correlating with MB1 and MB3 specificities.
    • Evidence suggests mAb 33.1 primarily reacts with the beta chain, and its expression is enhanced on activated B cells.

    Conclusions:

    • The 33.1 antigen is closely related to, but distinct from, MB antigens.
    • Polymorphisms within the 33.1 antigen exist, with specific variants associated with MB1 and MB3.
    • The preferential expression of 33.1 on activated B cells suggests a role in B-cell activation, though its precise function requires further investigation.