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Related Experiment Videos

Mobility of cells from solid tumors.

H Gershman, W Katzin, R T Cook

    International Journal of Cancer
    |March 15, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Tumor formation in hamsters was high for both NIL B and SV-NIL cells. In vitro cell mobility increased modestly in tumor-derived cells, suggesting in vivo survival selection enhances cell motility.

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    Area of Science:

    • Cell Biology
    • Cancer Research
    • Virology

    Background:

    • NIL B and SV-NIL cells are hamster-derived cell lines.
    • SV-NIL cells are transformed by Simian Virus 40 (SV40).
    • Tumorigenicity and cell mobility are key characteristics in cancer research.

    Purpose of the Study:

    • To investigate the in vitro cell mobility of NIL B and SV-NIL cells.
    • To compare the mobility of tumor-derived cells with their parental cell lines.
    • To assess the relationship between in vivo tumor formation and in vitro cell characteristics.

    Main Methods:

    • Cellular aggregates of NIL B and SV-NIL cells were cultured in agitated liquid medium.
    • Subcutaneous injections of cells were performed in Syrian hamsters to assess tumor formation.

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  • Cells from established tumors were cultured and their mobility, plating efficiency, saturation density, and doubling time were determined.

    • Main Results:

    • Both NIL B and SV-NIL cells demonstrated high tumor formation frequencies in vivo.
    • Tumor-derived cells exhibited slightly higher mobility in vitro compared to the original NIL B cells.
    • Plating efficiencies of tumor-derived cells were significantly lower than those of NIL B and SV-NIL cells.
    • No consistent patterns were observed for saturation density or doubling time in tumor-derived cells.

    Conclusions:

    • Selection for in vivo survival and tumor formation is associated with a modest increase in in vitro cell mobility.
    • The study provides insights into the phenotypic changes accompanying tumorigenesis.
    • Cellular adaptations for survival in vivo may influence in vitro migratory behavior.