Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Monocyte function is normal in quiescent psoriasis.

J P Geerdink, P H de Mulder, M R Franzen

    The Journal of Investigative Dermatology
    |February 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dutch translation, adaptation and validation of the OT-10 scale for orthostatic tremor.

    Clinical parkinsonism & related disorders·2023
    Same author

    The role of neoadjuvant or adjuvant chemotherapy for invasive bladder cancer Is there a benefit for survival or preserving the bladder?

    Urologic oncology·2011
    Same author

    Carbonic anhydrase IX expression is more predictive than prognostic in breast cancer.

    British journal of cancer·2007
    Same author

    [The Dutch Health Council report on palliative chemotherapy: possible confusion on ideas].

    Nederlands tijdschrift voor geneeskunde·2004
    Same author

    [Paraneoplastic syndromes in three patients with renal cell carcinoma].

    Nederlands tijdschrift voor geneeskunde·2004
    Same author

    [The current reimbursement system and future DRG system compared].

    Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege·2003

    This study found no intrinsic metabolic or functional abnormalities in monocytes from patients with mild psoriasis. These findings exclude a primary role for monocyte dysfunction in the condition.

    Area of Science:

    • Dermatology
    • Immunology
    • Cell Biology

    Background:

    • Psoriasis is a chronic inflammatory skin disease.
    • The role of peripheral blood monocytes in psoriasis pathogenesis is unclear.
    • Previous studies suggested potential monocyte abnormalities.

    Purpose of the Study:

    • To investigate potential intrinsic metabolic and functional abnormalities in monocytes from untreated patients with mild, quiescent psoriasis.
    • To assess glucose metabolism, lysosomal enzyme activity, signal processing, and phagocytic capacity of psoriatic monocytes.
    • To compare the in vitro maturation of normal and psoriatic monocytes.

    Main Methods:

    • Enzyme assays for glucose metabolism and lysosomal enzymes.
    • Measurement of cyclic AMP levels before and after hormonal stimulation.

    Related Experiment Videos

  • Luminol-amplified chemiluminescence for phagocytic capacity assessment.
  • In vitro culture to observe monocyte maturation patterns.

    • Main Results:

    • No significant differences were observed in the measured metabolic pathways or enzyme activities between psoriatic and normal monocytes.
    • Hormonal stimulation and phagocytic capacity assays showed no intrinsic abnormalities in psoriatic monocytes.
    • Monocyte maturation patterns in vitro were comparable between the two groups.

    Conclusions:

    • The concept of an intrinsic abnormality of the psoriatic monocyte is excluded by these findings.
    • The results suggest that observed monocyte alterations in psoriasis may be secondary to other factors.
    • Discrepancies with prior literature are discussed, highlighting potential reasons for differing conclusions.