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A calcium clamp technique in man.

O Tørring, H E Sjöberg

Acta Physiologica Scandinavica

|December 1, 1983

Summary

This study introduces a safe calcium clamp technique to precisely control ionized calcium levels in whole blood during infusion. This method prevents dangerous hypercalcemia and ensures stable calcium concentrations for medical procedures.

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Area of Science:

Biomedical Engineering
Clinical Pharmacology
Cardiovascular Medicine

Background:

Intravenous calcium infusions carry risks of cardiovascular complications.
Maintaining stable ionized calcium concentration in whole blood (WB-Ca++) is crucial for patient safety.

Purpose of the Study:

To develop and evaluate a novel method for controlled calcium infusion in humans.
To maintain a steady state of ionized calcium concentration at a predetermined level during infusion.

Main Methods:

Utilized a calcium chloride solution infused intravenously with an IMED 922H pump.
Monitored WB-Ca++ every 5-10 minutes using a calcium ion-selective electrode (NOVA 2).
Continuously adjusted infusion rates to achieve and maintain target WB-Ca++ levels.

Main Results:

Achieved a steady state WB-Ca++ of 1.45 +/- 0.01 mmol/l in females and 1.46 +/- 0.01 mmol/l in males within 25 minutes.
Maintained steady state levels for 155 minutes without significant side effects, apart from a transient blood pressure increase.
Demonstrated rapid attainment of target calcium levels, avoiding hypercalcemia (WB-Ca++ > 1.27 mmol/l).

Conclusions:

The developed calcium clamp technique is safe and effective for precise control of WB-Ca++.
This method is suitable for clinical scenarios requiring a stable and easily managed ionized calcium level.
The technique offers a reliable approach to mitigate risks associated with calcium infusions.

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