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Endogenous mouse leukemia viruses.

R Risser, J M Horowitz, J McCubrey

    Annual Review of Genetics
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Mouse genes influencing lymphoma are linked to murine leukemia viruses (MuLV). These retroviruses exhibit diverse host ranges and replication patterns, contributing to leukemia development.

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    Area of Science:

    • Virology
    • Oncology
    • Genetics

    Background:

    • Mouse genes influencing lymphoma incidence previously hindered viral etiology acceptance.
    • Mouse genes are now understood to be the DNA phase of murine leukemia viruses (MuLV).

    Purpose of the Study:

    • To elucidate the role of murine leukemia viruses (MuLV) in lymphoma development.
    • To explain how viral gene expression and interaction contribute to leukemogenesis.

    Main Methods:

    • Classification of MuLV based on host range (ecotropic, xenotropic, amphotropic) determined by gp70.
    • Identification of U3 sequences dictating tissue tropism.
    • Investigating MuLV genome expression induction via spontaneous, chemical, or transfection methods.

    Main Results:

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    • MuLV genomes are integrated at multiple mouse genome sites and can be induced to express.
    • Viral genomes can interact through recombination or trans complementation to enhance expression.
    • Expression of MCF-like gp70 is crucial, potentially stimulating cell proliferation.

    Conclusions:

    • Differential expression of endogenous MuLV has significant pathological consequences, particularly in lymphoma development.
    • Leukemogenesis involves complex interactions of multiple MuLV genomes.
    • Viral requirements for leukemia may include efficient replication and specific gp70 expression.