Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transmembrane signalling systems.

M Castagna

    Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Transmembrane signaling uses second messengers, ion channels, or endocytosis. This study details how cholera toxin and tumor promoters pathologically stimulate adenylate cyclase and protein kinase C systems.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Threonine 67 is a key component in the coupling of the NSS amino acid transporter KAAT1.

    Biochimica et biophysica acta. Biomembranes·2018
    Same author

    Antiproliferative effects of 5-fluorouracil and oxaliplatin in colon cancer cell lines: comparison of three different cytotoxicity assays.

    Journal of biological regulators and homeostatic agents·2013
    Same author

    Role of a conserved glycine triplet in the NSS amino acid transporter KAAT1.

    Biochimica et biophysica acta·2012
    Same author

    Evaluation of in vitro cytotoxicity of oxaliplatin and 5-fluorouracil in human colon cancer cell lines: combination versus sequential exposure.

    Journal of biological regulators and homeostatic agents·2012
    Same author

    Rathke's cleft cysts in children: clinical, diagnostic, and surgical features.

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2011
    Same author

    Distinct signaling mediates chloride secretion induced by tumor promoter bile-salts and phorbol esters in human colonic cells.

    International journal of oncology·2011
    Same journal

    Wnt activation during epileptogenesis prevents pathological immature dentate granule cell morphological changes in animal models of unilateral and bilateral temporal lobe epilepsy.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
    Same journal

    Protective effects of ACF210, a dual GLP-1/APJ receptor agonist, against cardiovascular-kidney-metabolic syndrome induced by T2D.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
    Same journal

    Tumor microenvironment-mediated interactions between macrophages and cancer cells define immunoregulatory transcriptional programs.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
    Same journal

    Photocontrol of zebrafish behavior with a photoswitchable ligand of nicotinic acetylcholine receptors.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
    Same journal

    Corrigendum to "Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization" [Biomed. Pharmacother. 141 (2021) 111883].

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
    Same journal

    Microfluidic human liver slices reveal antifibrotic effects of liraglutide via HSC deactivation and ECM remodeling.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
    See all related articles

    Area of Science:

    • Cellular Biology
    • Molecular Biology
    • Biochemistry

    Background:

    • Transmembrane signaling is crucial for cellular communication.
    • Key pathways include second messengers, ion channels, and receptor-mediated endocytosis.
    • Adenylate cyclase and protein kinase C are vital second-messenger systems.

    Purpose of the Study:

    • To analyze two major second-messenger systems: adenylate cyclase and protein kinase C.
    • To describe the pathogenic stimulation of these systems.
    • To highlight the roles of cholera toxin and tumor promoters.

    Main Methods:

    • Analysis of adenylate cyclase signaling pathways.
    • Investigation of protein kinase C signaling pathways.
    • Review of pathogenic mechanisms involving specific toxins and promoters.

    Related Experiment Videos

    Main Results:

    • Both adenylate cyclase and protein kinase C systems are activated by diverse biological signals.
    • Cholera toxin specifically stimulates the adenylate cyclase system.
    • Tumor promoters specifically activate the protein kinase C system.

    Conclusions:

    • Second-messenger systems are critical for transmembrane signaling.
    • Pathogenic agents can hijack these signaling pathways for detrimental effects.
    • Understanding these mechanisms is vital for studying cellular dysfunction and disease.