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Related Experiment Videos

[Structural and functional changes in thrombocytes in experimental atherosclerosis].

E A Gorbatenkova, O A Azizova, M Iu Dubrovin

    Biulleten' Eksperimental'Noi Biologii I Meditsiny
    |February 1, 1984
    PubMed
    Summary

    Experimental atherosclerosis in rabbits alters platelet membrane structure and function. Increased cholesterol in platelet membranes leads to enhanced aggregation, supporting the "membranous" hypothesis of atherogenesis.

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    Optical properties and electronic structure of Eu(III) complexes with HMPA and TPPO.

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2021

    Area of Science:

    • Biochemistry
    • Membrane Biology
    • Medical Research

    Context:

    • Experimental atherosclerosis in rabbits.
    • Utilizing electron paramagnetic resonance (EPR) with spin probes (stearic acid derivatives).

    Purpose:

    • To investigate the structural organization of rabbit platelets in experimental atherosclerosis.
    • To elucidate the role of cholesterol in platelet membrane alterations and aggregation.

    Summary:

    • Electron paramagnetic resonance studies revealed significant differences in phospholipid plasma membrane packing in rabbit platelets during experimental atherosclerosis.
    • These alterations were linked to a higher molar content of cholesterol.
    • Platelets exhibited increased aggregation properties, with shorter ADP-induced aggregation times.

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    Impact:

    • The findings support the primary role of membranotropic cholesterol activity in atherosclerosis.
    • This research validates the
    • membranous
    • hypothesis of atherogenesis.