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Related Experiment Videos

Circulating digitalis-like compounds in essential hypertension.

M A Devynck, M G Pernollet, J F Cloix

    Clinical and Experimental Hypertension. Part A, Theory and Practice
    |January 1, 1984
    PubMed
    Summary
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    Digitalis-like compounds in human plasma may contribute to hypertension. Researchers found these compounds in plasma from untreated hypertensive patients and those with a family history of high blood pressure.

    Area of Science:

    • Cardiovascular Physiology
    • Endocrinology
    • Pharmacology

    Background:

    • Inhibitors of the sodium-potassium pump (Na+/K+-ATPase) are implicated in blood pressure regulation.
    • Digitalis-like compounds, endogenous or exogenous, may influence cardiovascular homeostasis.
    • The presence and role of endogenous digitalis-like factors in human plasma remain under investigation.

    Purpose of the Study:

    • To investigate the presence and characteristics of digitalis-like compounds in human plasma.
    • To compare the effects of plasma extracts with ouabain in specific functional assays.
    • To explore the association between plasma digitalis-like activity and hypertension.

    Main Methods:

    • Assessed plasma extracts for digitalis-like properties using four assays: ouabain binding competition, inhibition of Na+/K+-ATPase, serotonin uptake inhibition in platelets, and central hypertensive effects.

    Related Experiment Videos

  • Compared plasma extracts from normotensive subjects (with and without a family history of hypertension), essential hypertensive patients (treated and untreated), and patients with chronic renal failure.

    • Main Results:

    • Plasma fractions from human subjects exhibited digitalis-like properties across all four tested assays.
    • Forty percent of untreated hypertensive patients and normotensive individuals with a hypertensive heredity showed high levels of inhibition.
    • Inhibition levels were modulated by antihypertensive treatments: enhanced with beta-blockers and decreased with diuretics.
    • No digitalis-like activity was detected in uremic plasma samples.

    Conclusions:

    • Human plasma contains compounds with digitalis-like activity.
    • This activity appears to be associated with essential hypertension and may be influenced by genetic predisposition and antihypertensive medications.
    • The findings suggest a potential role for endogenous digitalis-like substances in the pathophysiology of hypertension.