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Bronchopulmonary obstruction in children with respiratory virus infections
Insights
Respiratory syncytial virus and rhinovirus infections commonly cause bronchopulmonary obstruction in hospitalized children. Infants with bronchiolitis and asthmatic children are at highest risk for this condition.
Area of Science:
- Pediatric Pulmonology
- Infectious Diseases
- Respiratory Medicine
Background:
- Bronchopulmonary obstruction is a significant complication in children hospitalized with viral respiratory infections.
- Identifying at-risk populations is crucial for timely intervention and management.
Purpose of the Study:
- To investigate the prevalence of bronchopulmonary obstruction in children with confirmed viral respiratory infections.
- To identify specific viruses and patient groups associated with the development of bronchopulmonary obstruction.
Main Methods:
- Retrospective analysis of 873 children hospitalized with confirmed respiratory viral infections.
- Categorization of patients based on the presence of bronchopulmonary obstruction and identified viral pathogens.
- Analysis of risk factors including age, specific viral infections, and pre-existing conditions like asthma.
Main Results:
- 492 out of 873 children (56.4%) experienced bronchopulmonary obstruction.
- Respiratory syncytial virus (RSV) was the dominant cause (80%) among patients with bronchopulmonary obstruction.
- Rhinovirus infections also frequently led to bronchopulmonary obstruction (57% of rhinovirus patients).
Conclusions:
- Infants with RSV-induced bronchiolitis and children of all ages with bronchial asthma are key risk groups for developing bronchopulmonary obstruction during viral infections.
- RSV and rhinovirus are major contributors to virus-associated bronchopulmonary obstruction in children.
- Understanding these associations aids in targeted prevention and treatment strategies.
Abstract:
Among 873 children hospitalized with confirmed respiratory viral infections, 492 suffered from bronchopulmonary obstruction. Respiratory syncytial virus infections were dominant among the patients with bronchopulmonary obstruction (80%). The majority of patients with rhinovirus infections suffered from bronchopulmonary obstruction (57%). Two main groups of children at risk from developing bronchopulmonary obstruction during respiratory virus infections were found: 1) infants, suffering from bronchiolitis, mainly due to respiratory syncytial virus, and 2) children of all ages with bronchial asthma, among whom acute attacks were precipitated by virus infections, mainly rhinovirus and respiratory syncytial virus infections. The pathogenesis of bronchopulmonary obstruction during respiratory virus infections is discussed.