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An alpha globin pseudogene is located within the mouse t complex.

H S Fox, L M Silver, G R Martin

    Immunogenetics
    |January 1, 1984
    PubMed
    Summary
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    Restriction fragment length polymorphisms in the alpha-globin pseudogene (alpha-psi 4) were identified on mouse chromosome 17. This sequence is closely linked to the tufted locus within the t complex.

    Area of Science:

    • Genetics
    • Molecular Biology
    • Genomics

    Background:

    • Restriction fragment length polymorphisms (RFLPs) are variations in DNA sequences.
    • The alpha-globin pseudogene (alpha-psi 4) is located on chromosome 17.
    • T haplotypes are specific genetic arrangements found in mice.

    Purpose of the Study:

    • To identify and map RFLPs in the alpha-globin pseudogene (alpha-psi 4).
    • To investigate the genetic linkage of alpha-psi 4 within the mouse t complex.

    Main Methods:

    • Analysis of restriction fragment length polymorphisms (RFLPs).
    • Genetic mapping using partial t haplotypes.
    • Comparative analysis across different inbred mouse strains.

    Main Results:

    Related Experiment Videos

    • Two forms of the alpha-psi 4 sequence were found in different inbred mouse strains.
    • A third form of the alpha-psi 4 sequence was identified in complete t haplotypes.
    • The alpha-psi 4 sequence was mapped to the distal end of the t complex.
    • Evidence suggests close linkage between alpha-psi 4 and the tufted locus.

    Conclusions:

    • The alpha-globin pseudogene (alpha-psi 4) exhibits strain-specific RFLPs.
    • The alpha-psi 4 sequence is located within the mouse t complex, near the tufted locus.