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Human anterior uvea synthesizes lipoxygenase products from arachidonic acid
Investigative Ophthalmology & Visual Science
|February 1, 1984
Abstract:
Arachidonic acid is metabolized into biologically active prostaglandins, thromboxanes, and lipoxygenase products, leukotrienes. In the present study, the ability of human anterior uvea to synthesize lipoxygenase products from 14C-radiolabelled arachidonic acid is assessed. Following cyclooxygenase inhibition by indomethacin, human anterior uvea, similar to rabbit conjunctiva and anterior uvea, synthesizes chemotactic products 12-hydroxyeicosatetraenoic acid (HETE) and 5,12-DiHETE, indicating the presence of both 5- and 12-lipoxygenase enzyme activities.