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Beta-endorphin: effect on thermoregulation in aged monkeys.

M T Murphy, J M Lipton

    Neurobiology of Aging
    |January 1, 1983
    PubMed
    Summary

    Aging enhances the body's response to endogenous opioid peptides like beta-endorphin, leading to greater temperature changes in older primates. This suggests increased sensitivity of central nervous system opioid receptors with age.

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    Area of Science:

    • Neuroscience
    • Gerontology
    • Pharmacology

    Background:

    • Previous studies showed morphine causes greater hyperthermia in aged primates.
    • This suggests age-related changes in central nervous system (CNS) opioid receptor sensitivity.

    Purpose of the Study:

    • To investigate if aging increases responsiveness to endogenous opioid peptides.
    • To determine the effect of beta-endorphin on thermoregulation in young and aged primates.

    Main Methods:

    • Intracerebroventricular (ICV) injection of beta-endorphin (0.625-5 micrograms) into young and aged squirrel monkeys.
    • Core body temperature was monitored for 5 hours in different ambient temperatures (18°C and 30°C).

    Main Results:

    • Aged primates exhibited significantly greater hyperthermia compared to younger ones after beta-endorphin administration.
    • Beta-endorphin increased core temperature in aged monkeys more than in younger monkeys, especially in a hot environment.
    • In cold conditions, aged monkeys showed variable temperature responses (hyperthermia or hypothermia) to beta-endorphin, unlike young monkeys.

    Conclusions:

    • Central opioid receptor stimulation significantly impacts thermoregulation.
    • Aging leads to an increased responsiveness to the thermoregulatory effects of CNS opioid stimulation.

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