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Sphincter of Oddi motility.

J Toouli

    The British Journal of Surgery
    |April 1, 1984
    PubMed
    Summary

    Recent studies reveal normal sphincter of Oddi function involves phasic contractions and low tonic pressure. Abnormalities in sphincter of Oddi motility may link to conditions like pancreatitis and bile duct stones.

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    Area of Science:

    • Gastroenterology
    • Digestive Physiology

    Background:

    • Advancements in manometric and endoscopic tools have renewed focus on sphincter of Oddi function.
    • Understanding of normal sphincter of Oddi physiology and its motility abnormalities is growing through human and animal research.

    Purpose of the Study:

    • To detail the normal physiology of the sphincter of Oddi.
    • To identify potential motility abnormalities and their clinical associations.

    Main Methods:

    • Manometric studies to analyze sphincter of Oddi pressure and contractions.
    • Cineradiography to visualize the propulsive function of phasic contractions.
    • Assessment of responses to hormonal stimulation, such as cholecystokinin-octapeptide.

    Main Results:

    • Normal sphincter of Oddi function is characterized by phasic contractions superimposed on low tonic pressure.
    • Phasic contractions exhibit antegrade, simultaneous, and retrograde orientations, with a propulsive function.
    • Cholecystokinin-octapeptide inhibits phasic contractions and reduces sphincter tone.

    Conclusions:

    • Sphincter of Oddi motility abnormalities include high tone, altered contraction direction or frequency, and abnormal hormonal responses.
    • Disorders in sphincter of Oddi motility patterns are observed in preliminary human studies.
    • These motility abnormalities may be associated with choledocholithiasis, biliary dyskinesia, and idiopathic relapsing pancreatitis.

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