Ceftizoxime (FK 749) in vitro antibacterial activity

The minimal inhibitory concentrations of ceftizoxime, cefotaxime, moxalactam, cefoperazone, cefotiam and cefamandole were determined against various species of gram-negative bacteria and against Staphylococcus aureus. Ceftizoxime was more active against Enterobacteriaceae than cefamandole, cefotiam and cefoperazone and slightly more active than or similar to moxalactam and cefotaxime. Like cefotaxime and moxalactam, ceftizoxime was less active than cefoperazone against Pseudomonas aeruginosa and less active than cefamandole against S. aureus. Ceftizoxime was active against cephalosporinase-producing Enterobacteriaceae with a mean MIC of 0.19 mg/l. However, some isolates had an MIC above 32 mg/l.