Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fructose utilization by lung.

D K Das, A Neogi, H Steinberg

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |February 1, 1984
    PubMed
    Summary

    Mammalian lungs can metabolize fructose into fatty acids for phospholipid synthesis. This process is independent of nutritional or hormonal status, indicating a consistent role for fructose utilization in lung tissue.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Magnetic nanoparticle-catalysed synthesis of quinoline derivatives: A green and sustainable method.

    Heliyon·2024
    Same author

    Isoniazid preventive therapy among child contacts of TB patients, India.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2022
    Same author

    The effects of temperature and frequency dispersion on sound speed in bulk poly (vinyl alcohol) poly (N-isopropylacrylamide) hydrogels caused by the phase transition.

    Ultrasonics·2020
    Same author

    Nonreciprocal Linear Transmission of Sound in a Viscous Environment with Broken P Symmetry.

    Physical review letters·2018
    Same author

    Chest wall lymphomas: Fine needle aspiration cytodiagnosis and review of the literature.

    Cytopathology : official journal of the British Society for Clinical Cytology·2017
    Same author

    MRF-ANN: a machine learning approach for automated ER scoring of breast cancer immunohistochemical images.

    Journal of microscopy·2017

    Area of Science:

    • Biochemistry
    • Physiology
    • Metabolic Research

    Background:

    • Fructose metabolism pathways are well-established in tissues like the liver.
    • The role of fructose as a metabolic substrate in lung tissue remains less understood.
    • Investigating alternative metabolic pathways in mammalian lungs is crucial for understanding respiratory health.

    Purpose of the Study:

    • To elucidate the metabolic fate of fructose in mammalian lung tissue.
    • To determine the biochemical pathways involved in fructose utilization by the lung.
    • To assess the influence of hormonal and nutritional states on lung fructose metabolism.

    Main Methods:

    • Isolated, ventilated rat lungs were perfused with radiolabeled fructose ([U-14C]- or [5-3H]fructose).
    • Measurements included fructose utilization, water production, and lactate/pyruvate formation.
    • Analysis of incorporated radiolabel into lung lipids and enzyme activity assays were performed.

    Main Results:

    • Fructose was utilized by lung tissue, with [14C]fructose incorporated into lipids, including phospholipids.
    • Fructose metabolism occurred via phosphorylation, indicated by fructose-1-phosphate and fructose-1,6-diphosphate recovery.
    • Enzyme activities for fructose metabolism were unaffected by diabetes, hypophysectomy, or starvation; insulin did not impact lactate production.

    Conclusions:

    • Mammalian lungs can metabolize fructose, potentially synthesizing fatty acids for phospholipid biosynthesis.
    • Lung fructose utilization appears to follow a phosphorylation pathway involving key enzymes like fructokinase.
    • This metabolic pathway in the lung is resilient to changes in hormonal and nutritional conditions.

    Related Experiment Videos