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Dissolution kinetics of uric acid calculi.
The Journal of Urology
|April 1, 1984
Summary
Uric acid calculi dissolution rates were measured in vitro and applied to predict in vivo dissolution times. Tris(hydroxymethyl)aminomethane is preferred for irrigating uric acid stones.
Area of Science:
- Nephrology
- Urology
- Biochemistry
Background:
- Uric acid calculi are a common type of kidney stone.
- Dissolution therapy is a treatment option for uric acid stones.
Purpose of the Study:
- To investigate the in vitro dissolution rates of uric acid calculi.
- To estimate the time required for in vivo dissolution of uric acid calculi.
- To compare the efficacy of different agents for uric acid calculi dissolution.
Main Methods:
- In vitro dissolution studies of uric acid calculi using sodium bicarbonate, acetylcysteine, tris(hydroxymethyl)aminomethane, and tris(hydroxymethyl)aminomethane-E.
- Calculation of rate constants for dissolution.
- Application of rate constants to predict in vivo dissolution times.
Main Results:
- Rate constants for uric acid calculi dissolution were determined in vitro.
- The time for complete dissolution of uric acid calculi in patients on oral alkali therapy can be estimated.
- Tris(hydroxymethyl)aminomethane was identified as the preferred agent for irrigation in patients requiring dissolution therapy.
Conclusions:
- In vitro dissolution data can be used to estimate in vivo dissolution times for uric acid calculi.
- Tris(hydroxymethyl)aminomethane is the most effective agent for irrigating uric acid calculi in clinical settings.